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[DOI] [PubMed] [Google Scholar] 23.Tsai J-R, Wang H-M, Liu P-L, et al

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When researchers substituted a single amino acid, creating what would become the backbone of longer-acting analogs, the half-time rose to 6.7 minutes and metabolic clearance dropped by nearly half (a Journal of Clinical Endocrinology and Metabolism study measuring how a single D-Ala2 substitution increases the half-life and decreases the metabolic clearance of GHRH 1-29 in normal men)